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. 2022 Oct 20;54(11):1621–1629. doi: 10.1038/s41588-022-01192-y

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — The 24 major functional annotations were defined by Finucane et al.³⁹. Enrichment is the proportion of h²/proportion of SNPs. The horizontal dotted line indicates no enrichment (where proportion of h²/proportion of SNPs = 1). Error bars represent standard errors of the enrichment estimates. Asterisks indicate enrichment estimates are significant based on a Bonferroni-derived P value of < 2.08 × 10⁻³ (for 24 tests). Exact values of enrichment statistic, standard error, and P value can be found in Supplementary Table 16.