FIGURE 2.

Novel mitochondrial import surveillance pathways identified in yeast. The mitochondrial precursors over‐accumulation stress, indicated by aggregation of mitochondrial precursors or clogged import channel, activates multiple response pathways in yeast. These pathways include the UPR^am, mitoTAD, mitoCPR, and the mPOS‐mediated cell death pathways. These pathways often act to increase proteasomal activity to prevent protein aggregation and to limit protein import. In addition, an early UPR^mt is also activated at the first detection of protein aggregates in the mitochondria to increase cell survival