FIGURE 3.

(a). Upstream regulons that drive cell‐type‐specific state transitions toward aging (b). GO enrichment analysis indicated that downstream DEGs targeted by upstream regulons. (c). Network plot showing cell–cell communication changes between cell types in entorhinal cortex. Color of connecting lines indicates number of altered interaction pairs. Red, increased interactions; blue, decreased interactions. (d). Bar plot showing enrichment of GO terms or pathways in old‐specific ligand–receptor interactions. (e). Heatmap showing overlapping significance of aging‐related DEGs between entorhinal cortex and hippocampus