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The absence of FXR blocked the effect of Rc maintaining tight junctions in DSS-induced FXR−/- mice. The colons were collected for qPCR analysis, and the relative mRNA levels of claudin-1 (A), occludin (B), and ZO-1 (C) were measured; representative images of immunofluorescence of ZO-1 (D) in mouse colon sections (magnification: 200 ×). Data are shown as the mean ± SEM (n = 6). **p < 0.01 vs. the saline group.
