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. 2022 Nov 10;13:6823. doi: 10.1038/s41467-022-34581-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Diagram of the single-cell sequencing strategy for lymph node metastasis patients. b, c UMAP embedding plot showing identified clusters of all 118845 cells from paired PT (primary tumor) and LNMT (lymph node metastasized tumors) of 8 LNMT patients. Cells were colored according to their clusters (b) or tissues (c). The number of cells per cluster, per patient, and per tissue is summarized in Supplementary data 2. d Bar plots showing the differences in the major cell types between the 2 tissues (PT: n = 8 samples, LNM: n = 8 samples). Statistical testing was performed by a two-sided Wilcoxon test. Data are presented as mean values+/− SD. e The relative proportion of clusters between breast tumor and metastasis lymph node samples. Cell proportion has been normalized by sample size. f Spatial transcriptome analysis revealed the distribution of epithelial cells in the LNMT of 4 patients. Source data are provided as a Source Data file.