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. 2022 Nov 10;13:6803. doi: 10.1038/s41467-022-34568-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Sankey diagram showing the RBP-transcript-drug regulatory axes in cancer. b Drug correlations of differentially expressed transcripts upon the knockdown of PTBP1. c Comparison of decitabine sensitivity between KIAA1522-a6 high and low expression cancer cell lines (n = 392 for high expression cell lines, n = 393 for low expression cell lines). Each box represents the IQR and median of AUC values for each cell group, whiskers indicate 1.5 times IQR. P, two-sided Wilcoxon’s rank-sum test. d Crystal violet staining of the colony formation assay indicates the sensitivity of siNC-transfected or siPTBP1-transfected cells to decitabine, decitabine combined with carboplatin, or decitabine combined with navitoclax. The effect of treatments is shown for A2780 cells. qRT-PCR assays were applied to analyse the expression level of PTBP1 (e) and KIAA1522-a6 (f) after transfection by siPTBP1 for 48 h in A2780 cells. qRT-PCR assays were applied to analyze the expression level of KIAA1522-a6 in A2780 cells treated with Decitabine (g), Decitabine combined with Carboplatin (h), and Decitabine combined with Navitoclax (i). The relative expression of KIAA1522-a6 upon siKIAA1522-a6-1 and siKIAA1522-a6-2 transfection and the relative proliferation activity upon siKIAA1522-a6-MIX and decitabine treatment in the A2780 cell line (j) and the Huh7 cell line (k). SiKIAA1522-a6-MIX is the mixture of siKIAA1522-a6-1 and siKIAA1522-a6-2. P, two-sided Student’s t test p-value. n = 3 biologically independent samples. Error bars represent the means ± SDs.