Table 2.
Effect on the susceptibility to Sertoli cell-only (SCO) phenotype of the residues at position 13 of the HLA-DRβ1 molecule.
| Residue | Frequency (%) | P | OR [95% CI] | Classical MHC alleles | |
|---|---|---|---|---|---|
| SCO | Controls | ||||
| Ser | 51.40 | 37.75 | 1.32E−08 | 1.80 [1.47–2.21] | DRB1*03, DRB1*11, DRB1*13, DRB1*14, |
| Arg | 8.65 | 14.07 | 7.93E−04 | 0.55 [0.38–0.78] | DRB1*15, DRB1*16 |
| Tyr | 11.45 | 15.43 | 3.86E−02 | 0.72 [0.52–0.98] | DRB1*07 |
| Gly | 3.51 | 5.36 | 9.71E−02 | 0.63 [0.37–1.09] | DRB1*08, DRB1*12 |
| Phe | 11.21 | 13.40 | 1.96E−01 | 0.81 [0.59–1.11] | DRB1*01, DRB1*09, DRB1*10 |
| His | 13.79 | 13.99 | 7.26E−01 | 0.95 [0.71–1.27] | DRB1*04 |
The results of the combined analysis by logistic regression and the classical MHC alleles in our dataset that contain those amino acids are shown.
OR odds ratio for the reference residue, CI confidence interval.