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. 2022 Oct 28;9:981984. doi: 10.3389/fnut.2022.981984

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Copyright © 2022 Rasouli, Nayeri and Khodarahmi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The findings of this study at a quick glance. AFs in production/storage sites caused damage to target products and passed to consumers, leading to the progression of nCDs (Steps 1–5). Certain classes of PPs alleviated the side effects of AFs by modulating several critical signaling pathways involved in the pathogenesis of AFs. Indeed, these compounds could inhibit the formation of AFs by regulating expression of critical genes involved in biosynthetic pathways of AFs (Steps 6–8). Climate change markedly affects the occurrence of AFs, therefore, developing PPs-rich GM plants might be considered as a strategic policy to decrease the quantity of these mycotoxins. GMCs, genetically modified crops; PKD, Parkinson's disease; EP, epilepsy; IBD, inflammatory bowel disease; CD, cardiovascular diseases; KD, kidney diseases; LD, liver diseases; HP, hemophilia; SD, seizure disorder; CF, cystic fibrosis.