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. Author manuscript; available in PMC: 2023 Nov 8.
Published in final edited form as: Immunity. 2022 Sep 21;55(11):2118–2134.e6. doi: 10.1016/j.immuni.2022.08.017

Figure 5 -. Local Plasma Cells are Required to Protect the Olfactory Mucosa from Infection.

Figure 5 -

(a-b) OM VSV titers (a) and plasma nAb titers (b) from mice IP infected and treated with bortezomib (n = 8) 21d after infection or untreated (n = 9). At 35 dpi, mice rechallenged with VSV IN. Data pooled from two independent experiments. (c-d) OM VSV titers (c) and plasma nAb titers (d) from AIDCre/+ x iDTR mice (n = 4) or AID+/+ control mice (n = 4) previously IP infected with VSV. Diphtheria toxin administered 21 and 22 dpi. Mice challenged IN with VSV at d35. Data representative of two independent experiments. For (a-d), parametric unpaired t-test used for significance. ND (not detected), ns (not significant), * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. See also Figure S4.