. Author manuscript; available in PMC: 2022 Dec 1.

Published in final edited form as: J Pathol. 2022 Oct 14;258(4):325–338. doi: 10.1002/path.6006

Table 2.

Univariate survival analysis of CCOC proteomic clusters.

	# of events/n	Comparison cluster	Hazard Ratio (95% CI)	LRT p-value

Proteomic cluster (Reference: Metabolic)
OS	74 / 191	Fibrotic	1.50 (0.81–2.80)	0.194
		Coagulative	1.83 (1.05–3.21)
		Necrotic	1.43 (0.58–3.51)
PFS	75 / 155	Fibrotic	1.79 (0.96–3.36)	0.0365
		Coagulative	2.21 (1.27–3.85)
		Necrotic	1.63 (0.66–4.01)

Proteomics cluster (Reference: Metabolic)
OS	74 / 191	F,C,N^*	1.65 (1.01–2.69)	0.0413
PFS	75 / 155	F,C,N^*	1.97 (1.20–3.24)	0.0053

Proteomics cluster (Reference: Coagulative)
OS	74 / 191	M,F,N^*	0.65 (0.40–1.06)	0.0889
PFS	75 / 155	M,F,N^*	0.58 (0.36–0.93)	0.0261

Proteomic Cluster M: Metabolic active cluster; F: Fibrotic cluster; C: Coagulative cluster; N: Necrotic cluster