Table 4.
Multivariable analysis of GDA expression in clear cell ovarian carcinoma
| # of events / n | Comparison | Hazard Ratio (95% CI) | LRT P-value | |
|---|---|---|---|---|
|
| ||||
| Overall survival | 38 / 67 | |||
| GDA (IHC: h-score) - optimal cut point (clear cell) (reference: <230) | >=230 | 0.53 (0.27–1.05)F | 0.0751 | |
| Age at surgery | 1.03 (0.99–1.07)F | 0.0984 | ||
| Grade (reference: grade 1/2) | grade 3 | 0.25 (0.05–2.47)F | 0.3803 | |
| Stage (reference: I) | II-IV | 3.62 (1.69–8.73)F | 0.0005 | |
| Adjuvant treatment (reference: none) | chemo | 1.02 (0.24–9.5)F | 0.7144 | |
|
| ||||
| Diseases specific survival | 30 / 66 | |||
| GDA (IHC: h-score) - optimal cut point (clear cell) (reference: <230) | >=230 | 0.44 (0.21–0.92)F | 0.0350 | |
| Age at surgery | 1.01 (0.97–1.05)F | 0.5669 | ||
| Grade reference: grade 1/2) | grade 3 | 0.46 (0.05–61.63)F | 0.5288 | |
| Stage (reference: I) | II-IV | 3.72 (1.6–10.11)F | 0.0012 | |
| Adjuvant treatment (reference: none) | chemo | 0.97 (0.23–9.06)F | 0.7499 | |
|
| ||||
| Progression-free survival | 32 / 37 | |||
| GDA (IHC: h-score) - optimal cut point (clear cell) (reference: <230) | >=230 | 0.85 (0.33–2.21)F | 0.7553 | |
| Age at surgery | 0.98 (0.94–1.03)F | 0.4511 | ||
| Grade (reference: grade 1/2) | grade 3 | 3 (0.28–412.92)F | 0.1419 | |
| Stage (reference: I) | II-IV | 1.86 (0.76–5.43)F | 0.1458 | |
| Adjuvant treatment (reference: none) | chemo | 0.87 (0.2–8.22)F | 0.8462 | |
F
indicates that the Firth’s penalized maximum likelihood bias reduction method was used to estimate the hazard ratio.