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. 2022 Nov 8;23:1–15. doi: 10.1016/j.bioactmat.2022.10.004

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Effect and mechanism of intraoperative chemotherapy of gastric cancer by 5-FU + DDP/PLEL hydrogel on the postoperative peritoneal carcinomatosis model of mice. (A) Macroscopic feature of peri-gastric and mesenteric tumor nodules. Peri-gastric tumor nodules (denoted by white circles) and mesenteric tumor nodules (denoted by white arrows). Scale bar: 1 cm. (B) Photographs of tumors in each group. Data are presented as mean ± sd (n = 4). Scale bar: 1 cm. (C) Number of tumor nodules in different tumor volume ranges. (D) Weight of peri-gastric mesenteric tumor nodules on day 13 after different treatments. (E) Volume of ascites on day 13 after different treatments. Data are presented as mean ± sd (n = 4). (F) TUNEL assay and (Scale bar: 100 μm) Ki-67 staining (Scale bar: 50 μm). (G) Percentage of apoptotic cells calculated from the TUNEL results (H) Percentage of Ki67 positive cells after treatment. Data are presented as mean ± sd (n = 3). ∗∗p < 0.01, ∗∗∗p < 0.001.