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. 2022 Nov 9;23:69–79. doi: 10.1016/j.bioactmat.2022.09.027

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — The characteristics of TME and METTL14 might regulate immunosuppressive states in TME. (A) The t-SNE plot of 14 identified cell types in tumor lesions. (B, C, D) The relative proportion of macrophages in tumor tissues and normal tissues was shown by IF staining (CD163: M2 type of macrophages; iNOS: M1 type of macrophages; scale bars: 50 μm; **p < 0.01; n.s.: no significance). (E) METTL14 showed significant negative associations with infiltrating levels of CD4⁺ T cells (r = −0.294, p = 3.83e-06) and macrophages (r = −0.232, p = 3.26e-04) in sarcoma via the TIMER database. (F, G) METTL14 had a significantly positive association with IL1A (r = 0.138, p = 2.55e-02) of M1 type and negative correlations with CD163 (r = −0.261, p = 2.17e-05) and VSIG4 (r = −0.352, p = 6.88e-09) of M2 type of macrophages.