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. 2022 Nov 9;23:69–79. doi: 10.1016/j.bioactmat.2022.09.027

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — The dual-targeting effects of (pMETTL14+RS09)@cRGD-M. (A, C) pMETTL14 was labeled with FITC (green) and the membrane was labeled with DiD (red). Tumor cell-targeting ability of (pMETTL14+RS09)@M and (pMETTL14+RS09)@cRGD-M was investigated in vitro (scale bar: 20 μm; **p < 0.01). (B, D) The tumor accumulation ability of (pMETTL14+RS09)@cRGD-M was investigated in vivo (**p < 0.01). (E, F) Macrophage-targeting ability of (pMETTL14+RS09)@M and (pMETTL14+RS09)@cRGD-M was investigated in vitro (scale bar: 20 μm; n.s.: no significance).