Table 2.
Descriptive Characteristics of the CN and AD participants [mean ± SD (min-max)].
| Characteristic/Test | All | CN | AD | t or χ2 | P |
|---|---|---|---|---|---|
| No. | 25 | 10 | 15 | ||
| Sex, M/F | 11/14 | 4/6 | 7/8 | 0.11 | 0.74 |
| Age, yr | 78.4 ± 4.4 (69–85) | 78.9 ± 5.2 (69–85) | 78.1 ± 3.9 (70–84) | 0.42 | 0.68 |
| Education, yr | 12.4 ± 2.4 (9–16) | 13.0 ± 2.3 (9–16) | 11.9 ± 2.5 (9–16) | 1.09 | 0.29 |
| MMSE | 22.9 ± 3.6 (15–29) | 26.2 ± 2.2 (24–29) | 20.7 ± 2.4 (15–23) | 5.76 | <0.001* |
| ApoE4 (+)/(−) | 13/12 | 4/6 | 9/6 | 0.96 | 0.33 |
| BMI | 22.4 ± 3.9 (14.2–30.1) | 23.0 ± 5.6 (14.2–30.1) | 22.0 ± 2.4 (18.8–26.4) | 0.57 | 0.58 |
| DPA-713 TSPO-PET results | |||||
| Braak 1–3-TSPO-BPND (medial temporal area) | 0.14 ± 0.07 (0.04–0.28) | 0.10 ± 0.05 (0.04–0.16) | 0.18 ± 0.07 (0.07–0.28) | −3.23 | 0.004* |
| Braak 4-TSPO-BPND (limbic area) | 0.09 ± 0.07 (−0.01–0.24) | 0.07 ± 0.07 (0.00–0.24) | 0.10 ± 0.07 (−0.01–0.22) | −1.12 | 0.27 |
| Braak 5-TSPO-BPND (neocortical area) | 0.00 ± 0.04 (−0.06–0.10) | −0.01 ± 0.05 (−0.06–0.10) | 0.00 ± 0.04 (−0.05–0.08) | −0.54 | 0.60 |
*P<0.05.
Abbreviations: CN, cognitively normal; AD, Alzheimer’s disease; MMSE, Mini-mental state examination; BMI, body mass index; TSPO, translocator protein: BPND, binding potential.