Table 1.
Genes and gene deletion mutants modulating the expression of the Rtc system
| Name | Description | Effect | Dependent on |
||
|---|---|---|---|---|---|
| RtcR | RtcB | RtcA | |||
| ΔahpC | Peroxidase; forms alkyl hydroperoxide reductase with peroxiredoxin reductase ahpF [AhpC]10[AhpF]2 | ↑ | YES | YES | YES |
| Δgora | GSH oxidoreductase: in operon with 23S rRNA methyltransferase | ↑ | YES | YES | NO |
| Δhfq | RNA binding protein: regulation of the activity of small RNA species | ↑/↓ | NO | – | – |
| ΔmazF | Ribonuclease; toxin component of a toxin-antitoxin system | ↑ | YES | YES | YES |
| ΔrnhAb | Endoribonuclease (RNase H); digestion of RNA in DNA-RNA hybrids | ↑ | NO | – | – |
| ΔrppH | RNA pyrophosphohydrolase; hydrolysis of 5′-triphosphate mRNA end, prior to degradation by RNase E | ↑ | NO | – | – |
| ΔsrmB | RNA helicase; assembly of the 50S ribosomal subunit | ↑ | – | – | – |
| ΔybaKa | Cys-tRNAPro and Cys-tRNACys deacylase; tRNA editing | ↑ | YES | YES | YES |
| ΔyobFa | stress-induced peptide; in operon with ribosome-associated CspC | ↑ | YES | YES | NO |
| rof | transcription antiterminator; interaction with Rho terminator protein | ↑ | NO | – | – |
| yedV | histidine kinase; in operon with yedW which confers drug resistance | ↑ | NO | – | – |
| yheS | ABC-F protein; mediation of antibiotic resistance via ribosomal protection | ↓ | – | – | – |