TABLE 2.
Analysis of Cox-1 and Cox-3 mRNA levels, SIRT1 and PGC-1α protein levels in the amygdala (A,C) and in the prefrontal cortex (B,D) of 5-HTT+/+ and 5-HTT–/– rats.
| Gene | Amygdala (A) | Prefrontal cortex (B) | ||
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| 5-HTT+/+ | 5-HTT–/– | 5-HTT+/+ | 5-HTT–/– | |
| Cox-1 | 100 ± 9 | 128 ± 11 | 100 ± 13 | 132 ± 11 |
| Cox-3 | 100 ± 5 | 104 ± 5 | 100 ± 4 | 197 ± 20*** |
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| Protein | Amygdala (C) | Prefrontal cortex (D) | ||
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| 5-HTT+/+ | 5-HTT–/– | 5-HTT+/+ | 5-HTT–/– | |
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| SIRT1 | 100 ± 4 | 198 ± 27** | 100 ± 21 | 152 ± 8* |
| PGC-1α | 100 ± 7 | 119 ± 12 | 100 ± 3 | 109 ± 14 |
The data are expressed as a percentage of 5-HTT+/+ (set at 100%) and represent the mean ± SEM of 7 to 10 independent determinations. *p < 0.05, **p < 0.01, ***p < 0.001 vs. 5-HTT+/+ (Unpaired t-test).