TABLE 3.

Analysis of Cox-1 and Cox-3 mRNA levels, SIRT1 and PGC-1α protein levels in the amygdala (A,C) and in the prefrontal cortex (B,D) of 5-HTT^+/+ and 5-HTT^–/– rats exposed to fear extinction recall (FCR).

Gene	Amygdala (A)		Prefrontal cortex (B)
	Δ5-HTT+/+/FCR	Δ5-HTT–/–/FCR	Δ5-HTT+/+/FCR	Δ5-HTT–/–/FCR
Cox-1	+39% ± 17	+5% ± 9	−18% ± 17	+34% ± 22
Cox-3	+14% ± 8	+15% ± 8	+61% ± 21*	−14% ± 6
Protein	Amygdala (C)		Prefrontal cortex (D)
	Δ5-HTT+/+/FCR	Δ5-HTT–/–/FCR	Δ5-HTT+/+/FCR	Δ5-HTT–/–/FCR
SIRT1	+21% ± 12	+14% ± 16	+87% ± 39*	−38 ± 10
PGC-1α	+6% ± 12	−5% ± 10	+32% ± 6	+5 ± 12

The data are expressed as a percentage of 5-HTT^+/+/naive and 5-HTT^–/–/naive and represent the mean ± SEM of 6–10 independent determinations. *p < 0.05 vs. 5-HTT^+/+/naïve (Two-way Anova with Tukey).