Figure 1.

Recombinant plague antigen vaccine study design to evaluate germinal center B cell and T cell responses and long-lived antibody responses. (A) Schematic showing the study timeline and timepoints for immunization, draining lymph node collection, and blood collection from immunized mice. Mice were immunized and boosted intramuscularly with antigen and adjuvant at day 0 and day 16. At day 126, mice were injected intraperitoneally with F1V antigen (no adjuvant) and the antibody recall response was measured 7 days later (day 133). (B) Table shows the various antigen + adjuvant vaccine groups.