Fig. 5. Illustrative case (Case 12). Preoperative MRI and CT images (A-C) and postoperative MRI and CT images (D-F). A 4-year-old female patient presented with left side weakness (grade 3). The day before surgery, motor weakness aggravated to grade 2 and diplopia occurred. Images revealed pontine tumor with tumor bleeding. The tumor was removed partially and the patient was diagnosed as diffuse midline glioma, H3 K27M altered. After resection, diplopia disappeared and weakness also improved to nearly normal for 9 months till progression.