Table 2. Factors contributing to OS and PFS on DMG.

Factor (cut-off value)		OS (months)		p-value	PFS (months)		p-value
		Median	95% CI		Median	95% CI
Age				0.335			0.747
	<20 yr	9.638	7.178–12.097		4.111	2.634–5.588
	≥20 yr	11.349	7.706–14.992		3.700	1.592–5.808
Sex				0.486			0.894
	Male	9.407	4.666–14.149		3.750	1.696–5.804
	Female	11.114	9.277–12.951		4.000	2.287–5.713
Size				0.054			0.387
	≥4 cm	9.251	7.392–11.109		3.583	1.921–5.245
	<4 cm	12.371	8.187–16.556		4.429	2.339–6.518
Location				0.871			0.275
	Brainstem	10.296	7.506–13.087		4.250	2.576–5.924
	Non-brainstem	10.417	7.546–13.287		3.286	1.247–5.324
Operation				0.570			0.423
	Resection	10.905	6.780–15.030		4.500	2.217–6.783
	Biopsy	10.175	8.232–12.118		3.455	1.951–4.958
KI-67 LI				0.272			0.692
	≥20%	10.375	8.154–12.596		3.375	1.453–5.297
	<20%	13.800	6.304–21.296		3.800	0.676–6.924
Adjuvant Tx				0.604			0.387
	RTx	9.667	6.047–13.286		4.500	2.492–6.508
	CCRTx	11.525	8.710–14.340		3.000	1.371–4.629

OS, overall survivial; PFS, progression-free survival; DMG, diffuse midline glioma; CI, confidence interval; LI, labeling index; RTx, radiation therapy; CCRTx, concurrent chemoradiation therapy