Table 2. Progression-free survival rates in intracranial anaplastic meningioma.
Variables | No. of progression/no. of patients (%) | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|---|
Survival (month, mean±SE) | p value (log-rank) | HR | 95% CI | p value | |||
Overall | 34/48 (70.8) | 13.9±2.6 | - | ||||
Age (years) | 0.552 | ||||||
<57 | 16/20 (80.0) | 9.6±10.4 | |||||
≥57 | 18/28 (64.3) | 13.9±1.7 | |||||
Sex | 0.016 | 1.387 | 0.673–2.859 | 0.375 | |||
Male | 18/30 (60.0) | 28.4±8.7 | |||||
Female | 16/18 (89.9) | 8.8±1.9 | |||||
Diagnosis type | <0.001 | 1.569 | 0.614–4.006 | 0.346 | |||
Primary | 16/28 (57.1) | 29.7±10.9 | |||||
Secondary | 18/20 (90.0) | 5.7±0.8 | |||||
Location | 0.080 | 1.987 | 0.923–4.278 | 0.079 | |||
Superficial | 22/35 (62.9) | 17.9±8.1 | |||||
Deep or skull base | 12/13 (92.3) | 6.2±3.9 | |||||
Tumor size | 0.083 | ||||||
<4.5 cm | 17/19 (89.5) | 12.5±3.7 | |||||
≥4.5 cm | 17/29 (58.6) | 26.7±13.4 | |||||
Peritumoral edema | 0.668 | ||||||
Mild | 12/18 (66.7) | 14.7±6.3 | |||||
Moderate to severe | 22/30 (73.3) | 13.9±4.7 | |||||
Tumor shape | 0.470 | ||||||
Round | 13/17 (76.5) | 13.9±2.2 | |||||
Mushroome | 21/31 (67.7) | 15.4±5.9 | |||||
Preoperative ECOG | 0.278 | ||||||
0 or 1 | 15/24 (62.5) | 17.3±10.3 | |||||
≥2 | 19/24 (79.2) | 13.0±3.3 | |||||
Extent of resection | <0.001 | 1.896 | 0.858–4.191 | 0.114 | |||
GTR | 22/36 (61.1) | 26.7±9.6 | |||||
STR | 12/12 (100) | 5.7±0.6 | |||||
Simpson grade | 0.125 | ||||||
1 or 2 | 20/31 (64.5) | 17.9±9.6 | |||||
3 or 4 or 5 | 14/17 (82.4) | 8.8±3.5 | |||||
Adjuvant radiation | <0.001 | 0.113 | 0.034–0.374 | <0.001 | |||
No | 15/16 (93.7) | 4.4±0.7 | |||||
Yes | 19/32 (59.4) | 29.7±4.2 |
SE, standard error; HR, hazard ratio; 95% CI, 95% confidence interval; ECOG, Eastern Cooperative Oncology Group; GTR, gross total resection; STR, subtotal resection