Table 3. Overall survival rates in intracranial anaplastic meningioma.
Variables | No. of progression/no. of patients (%) | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|---|
Survival (month, mean±SE) | p value (log-rank) | HR | 95% CI | p value | |||
Overall | 25/48 (52.1) | 56.90±16.75 | |||||
Age | 0.881 | ||||||
<57 yrs | 12/20 (60) | 50.73±31.31 | |||||
≥57 yrs | 13/28 (46.4) | 56.9±15.59 | |||||
Sex | 0.055 | 1.377 | 0.615–3.084 | 0.437 | |||
Male | 12/30 (46.7) | 77.70 | |||||
Female | 13/18 (72.2) | 32.93±4.71 | |||||
Diagnosis type | 0.049 | 0.523 | 0.125–2.182 | 0.374 | |||
Primary | 13/28 (53.6) | 81.27 | |||||
Secondary | 12/20 (60.0) | 36±5.48 | |||||
Location | 0.146 | 2.214 | 0.909–5.394 | 0.080 | |||
Superficial | 16/35 (51.4) | 61.70±19.23 | |||||
Deep or skull base | 9/13 (69.2) | 18.60±8.91 | |||||
Tumor size | 0.341 | ||||||
<4.5 cm | 12/19 (63.2) | 37.53±18.40 | |||||
≥4.5 cm | 13/29 (51.7) | 77.70 | |||||
Peritumoral edema | 0.918 | ||||||
Mild | 10/18 (61.1) | 50.73±31.55 | |||||
Moderate to severe | 15/30 (53.3) | 56.90±15.97 | |||||
Tumor shape | 0.602 | ||||||
Round | 10/17 (64.7) | 77.70 | |||||
Mushroome | 15/31 (51.6) | 49.90±10.25 | |||||
Preoperative ECOG | 0.267 | ||||||
0 or 1 | 10/24 (45.8) | 77.70 | |||||
≥2 | 15/24 (66.7) | 49.90±13.80 | |||||
Extent of resection | <0.001 | 2.296 | 0.926–5.693 | 0.073 | |||
GTR | 14/36 (44.4) | - | |||||
STR | 11/12 (91.7) | 28.90±11.29 | |||||
Simpson grade | 0.058 | ||||||
1 or 2 | 14/31 (51.6) | 81.27 | |||||
3 or 4 or 5 | 11/17 (64.7) | 32.93±14.83 | |||||
Adjuvant radiation | <0.001 | 0.161 | 0.036–0.731 | 0.018 | |||
No | 12/16 (75.0) | 18.20±10.71 | |||||
Yes | 13/32 (46.9) | 81.27 |
SE, standard error; HR, hazard ratio; 95% CI, 95% confidence interval; ECOG, Eastern Cooperative Oncology Group; GTR, gross total resection; STR, subtotal resection