Table 4. Relapse patterns and treatment at progression in intracranial anaplastic meningioma.

No	Sex	Age (yr)	Primary or secondary	Location	Extent of resection	Adjuvant therapy	PFS (mo)	Relapse patterns	Treatment at recurrence	Chemotherapy agent	Effect of chemotherapy	Survival status	OS (mo)
1	F	46	Secondary	Sphenoidal ridge	STR	-	6	ICD	Observation	-	-	Death	29
2	F	56	Secondary	Spheno-orbital	STR	-	1	ICD	Op	-	-	Death	36
3	M	52	Primary	Parasagittal	GTR	RTx	27	Local, ICD, ECD (lung)	CTx, Op	Hydroxyurea	PD	Death	78
4	M	46	Secondary	Sphenoid ridge	STR	-	4	Local	Op	-	-	Death	17
5	F	66	Secondary	Frontal	GTR	-	6	Local, ICD	Op, SRS	-	-	Death	18
6	M	66	Primary	Parietal	GTR	-	15	Local, ICD	Op	-	-	Death	28
7	F	48	Primary	Temporal	STR	-	15	ICD	Op	-	-	Death	51
8	F	67	Primary	Tuberculum sellae	STR	-	12	Local, ECD (lung)	Op	-	-	Death	19
10	F	55	Secondary	Sphenoid ridge	GTR	-	4	LMS	Op, RTx	-	-	Death	12
12	F	49	Primary	4th ventricle	GTR	RTx	18	LMS	RTx	-	-	Death	81
13	M	60	Secondary	Frontal	GTR	RTx	14	ICD	Op #2, SRS	-	-	Death	62
15	M	51	Secondary	Temporal	GTR		4	ICD	Op, SRS, CTx	ICE #2	PD	Death	14
										Adriamycin #2	PD
										Irinotecan #1	PD
16	M	56	Primary	Convexity	GTR	RTx	35	Local, ICD	Op #2, CTx, SRS	TMZ #6	PD	Alive	100
18	M	32	Primary	Sphenoid ridge	GTR	RTx	66	Local, ECD (lung)	SRS, lung	-	-	Alive	90
21	M	68	Primary	Parasagittal	STR	-	4	Local, ICD	Denial to treat	-	-	Death	8
22	M	59	Secondary	Parasagittal	STR	-	5	ICD (skull base)	SRS #3	-	-	Death	57
23	F	72	Primary	Sphenoid ridge	GTR	RTx	13	Local, ICD	SRS #2	-	-	Alive	72
25	F	77	Primary	Scalp, convexity	STR	RTx	32	ICD, ECD (lung)	Denial to treat	-	-	Death	50
27	M	57	Primary	Intraventricular	STR	RTx	6	Local	Observation	-	-	Death	12
29	M	69	Primary	Convexity	GTR	RTx	30	Local	SRS	-	-	Death	38
30	F	75	Secondary	Falx	GTR	RTx	52	Local, ICD	Denial to treat	-	-	Alive	63
31	F	63	Primary	Frontal	GTR	RTx	6.7	Local, ECD (spine)	Op (brain, spine), SRS	-	-	Death	16
32	M	53	Secondary	Convexity	GTR	RTx	28	ICD	Op, RTx	-	-	Alive	61
33	F	50	Secondary	Convexity	GTR	-	6	Local, LMS	Denial to treat	-	-	Death	8
34	F	77	Secondary	Convexity	GTR	-	2	ICD, ECD (multiple bone)	OP, SRS, RTx	-	-	Death	8
35	M	46	Primary	Intraventricular	GTR	RTx	6	ICD, ECD (rib)	OP, RTx, CTx	ICE #3	PD	Death	32
36	F	56	Primary	Parasagittal	GTR	-	10	Local, ICD	OP, RTx, CTx	ICE #2	PD	Death	30
										Avastine #3	PD
										Sunitinib #2	PD
37	M	52	Secondary	Sphenoid ridge	GTR	CTx (TMZ #4)	4	Local, LMS	OP, SRS, CTx, WBRT	ICE #6	SD (6 mo) → PD	Death	15
38	M	60	Primary	Convexity	GTR	RTx	9	Local	OP, CTx	ICE #6	SD (5 mo)	Death	30
										Avastine #6	PD
39	F	57	Secondary	Parietal	STR	CKRS	8	ICD	OP, CTx	ICE #4	SD (4 mo) → PD	Death	33
42	M	59	Secondary	Convexity	GTR	RTx	17	ICD	OP	-	-	Alive	32
43	M	57	Secondary	Convexity, scalp	STR	CTx (ICE #6)	13	ICD	SRS #2, CTx	ICE #6	PR → PD	Alive	30
										Avastine #3	PD
44	F	71	Secondary	Convexity	GTR	No	9	Local	Salvage RTx	-	-	Alive	26
45	M	47	Secondary	Convexity	GTR	No	4	4 ICD, ECD (scalp)	CTx	ICE #4	SD (7 mo) → PD	Alive	25

PFS, prgression-free survival; OS, overall survival; M, male; F, female; GTR, gross total resection; STR, subtotal resection; ICD, intracranial dissemination; LMS, leptomeningeal seeding; ECD, extracranial dissemination; CKRS, CyberKnife radiosurgery; WBRT, whole brain radio therapy; ICE, ifosfamide, carboplatin, etoposide; TMZ, temozolomide; Op, operation; RTx, radiation therapy; SRS, stereotactic radiosurgery; CTx, chemotherapy; PD, progressive disease; SD, stable disease