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. 2022 Oct 28;12:1009064. doi: 10.3389/fonc.2022.1009064

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Copyright © 2022 Amidi and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The circadian disruption hypothesis of cancer- and cancer treatment-related symptoms. Cancer and its treatment, as well as associated behavioral and psychological changes may (A) directly impact the circadian system resulting in circadian disruption in both biological and behavioral rhythms, and (B) lead to a dysregulated immune response and endocrine disruption, which are themselves bidirectionally linked and may both impact the circadian system. Circadian disruption may result in cancer- and treatment-related symptoms (CTRS) or exacerbate pre-existing symptoms (C). Finally, it is important to note that once manifested, chronic CTRS burden may further alter both behavioral and pathophysiological factors creating a self-perpetuating negative loop (D). Created with BioRender.com.