Table 1.
Demographic and Clinical Characteristics of Participants in Cohort 1 (Year 0) and Cohort 2 (Year 1)
| Characteristics | Cohort 1 (Year 0) |
Cohort 2 (Year 1) |
|||||
|---|---|---|---|---|---|---|---|
| CD (n=660) | UC (n=1,025) | Total (n=1,685) | CD (n = 705) | UC (n = 944) | Total (n = 1,649) | ||
| Age (yr) | 36.1 ± 13.8 | 49.2 ± 15.9 | 44.1 ± 16.4 | 37.3 ± 14.4 | 49.8 ± 15.6 | 44.4 ± 16.3 | |
| Male sex | 464 (70.3) | 613 (59.8) | 1,077 (63.9) | 509 (72.2) | 572 (60.6) | 1,081 (65.6) | |
| Duration of disease (mo) | 84.4 ± 65.4 | 82.9 ± 70.6 | 83.5 ± 68.6 | 93.3 ± 67.8 | 90.5 ± 73.2c | 91.7 ± 70.9 | |
| CDAI scorea | 112.0 ± 76.5d | 113.9 ± 87.7e | |||||
| Partial Mayo scorea | 3.0 ± 2.0f | 2.6 ± 2.3c | |||||
| Age at onset of disease | |||||||
| A1: < 17 yr | 89 (13.5) | 17 (1.7) | 106 (6.3) | 92 (13.1) | 17 (1.8) | 109 (6.6) | |
| A2: 17–40 yr | 460 (69.7) | 511 (49.9) | 971 (57.6) | 492 (69.8) | 453 (48.0) | 945 (57.3) | |
| A3: > 40 yr | 111 (16.8) | 497 (48.5) | 608 (36.1) | 121 (17.2) | 474 (50.2) | 595 (36.1) | |
| Disease locationb | |||||||
| L1: ileal | 155 (23.5) | 183 (26.0) | |||||
| L2: colonic | 124 (18.8) | 114 (16.2) | |||||
| L3: ileocolonic | 363 (55.0) | 391 (55.5) | |||||
| L4: isolated upper gastrointestinal | 20 (3.0) | 20 (2.8) | |||||
| Disease behavior | |||||||
| B1: non-stricturing/non-penetrating | 424 (64.2) | 424 (60.1) | |||||
| B2: stricturing | 153 (23.2) | 164 (23.3) | |||||
| B3: penetrating | 83 (12.6) | 117 (16.6) | |||||
| p: perianal disease modifier | 237 (35.9) | 162 (23.0) | |||||
| Extent of UC | |||||||
| E1: ulcerative proctitis | 372 (36.3) | 330 (35.0) | |||||
| E2: left sided UC | 282 (27.5) | 298 (31.6) | |||||
| E3: extensive UC | 371 (36.2) | 315 (33.4) | |||||
| Disease activity at baseline | |||||||
| Remission | 472 (72.4) | 244 (23.8) | 716 (42.7) | 499 (71.2) | 401 (42.6) | 900 (54.8) | |
| Mild | 110 (16.9) | 601 (58.7) | 711 (42.4) | 107 (15.3) | 338 (35.9) | 445 (27.1) | |
| Moderate | 67 (10.3) | 107 (10.5) | 173 (10.3) | 93 (13.3) | 137 (14.5) | 230 (14.0) | |
| Severe | 0 | 67 (6.5) | 67 (4.0) | 1 (0.1) | 66 (7.0) | 67 (4.1) | |
| Prior surgery related to IBD | 234 (35.5) | 24 (2.3) | 258 (15.3) | 244 (34.6) | 23 (2.4) | 267 (16.2) | |
| Comorbidities | |||||||
| Osteopenia | 36 (5.5) | 42 (4.1) | 78 (4.6) | 26 (3.7) | 33 (3.5) | 59 (3.6) | |
| Osteoporosis | 15 (2.3) | 32 (3.1) | 47 (2.8) | 18 (2.6) | 20 (2.1) | 38 (2.3) | |
| Others | 6 (0.9) | 12 (1.2) | 18 (1.1) | 27 (3.8) | 16 (1.7) | 43 (2.6) | |
Values are presented as mean±standard deviation or number (%).
a
Twelve months before baseline for cohort 1 (Year 0) and 1 year for cohort 2 (Year 1).
b
Multiple responses allowed.
c
(n=943).
d
(n=649).
e
(n=700).
f
(n=1,019).
CD, Crohn's disease; UC, ulcerative colitis; CDAI, Crohn's Disease Activity Index; IBD, inflammatory bowel disease.