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. 2022 Oct 28;13:1001956. doi: 10.3389/fimmu.2022.1001956

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Copyright © 2022 Ogbechi, Huang, Clanchy, Pantazi, Topping, Darlington, Williams and Stone

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PQS reduces inflammation-associated gene expression in polarized macrophages. In murine bone marrow-derived macrophages the expressions of (A) IL-1β, (B) IL-6, (C) TNF, (D) IDO1 and (E) IDO2 were measured after polarisation to M0, M1 and M2 macrophages in the presence of PQS (0.5-20 μM). In human THP-1-derived M0, M1 and M2 macrophages cultured in the presence of PQS, the expressions of (F) IL-1β, (G) IL-6, (H) IL-10, (I) TNF, (J) IDO1 and (K) IDO2 were measured; n = 3, *p<0.05, **p<0.01, ***p<0.001.