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. 2022 Oct 28;13:1025551. doi: 10.3389/fphar.2022.1025551

FIGURE 4.

FIGURE 4

BCATc Inhibitor 2 alleviates OA-induced expression of lipogenesis-related genes. (A–F) LO2 cells were incubated with 0.5 mm Oleic acid with or without 10 mm BCAAs for 48 h qPCR was performed to determine the expression of ACLY (A), FASN (B), ACC (C), SCD1 (D), ATGL (E), HSL (F). (G–M) LO2 cells were incubated with 0.5 mM Oleic acid and 0, 10, 20 µM BCATc Inhibitor 2 for 48 h qPCR was performed to determine the expression of ACLY (G), FASN (H), ACC (I), SCD1 (J), ATGL (K), HSL (L). (M,N) LO2 cells were incubated with 0.5 mm Oleic acid with or without 10 mm BCAAs or BCATc Inhibitor 2 for 48 h. The expression of SREBP1 was detected by western blot. Data are shown as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ns p > 0.05. INc: BCATc Inhibitor 2.