. 2022 Oct 28;10:976012. doi: 10.3389/fped.2022.976012

Table 3.

Sequential linear regressions examining associations between treatment exposures, BMI, prevalent neuropathy, and lifestyle factors on physiological cost index in adult survivors of childhood acute lymphoblastic leukemia.

	n	Physiological cost index
		Model A (R² = 0.08)			Model B (R² = 0.10)			Model C (R² = 0.11)^a
		mean	SE	p	mean	SE	p	mean	SE	p
Cranial Radiation
Yes	549	0.54	0.04	0.73	0.53	0.04	0.19	0.53	0.03	0.21
No	608	0.55	0.03	REF	0.54	0.03	REF	0.51	0.04	REF
Anthracyclines
Yes	890	0.56	0.03	0.08	0.55	0.03	0.05	0.53	0.04	0.07
No	267	0.53	0.03	REF	0.52	0.03	REF	0.51	0.04	REF
Corticosteroids
Yes	1,150	0.53	0.01	0.64	0.52	0.01	0.64	0.51	0.01	0.78
No	7	0.55	0.06	REF	0.55	0.07	REF	0.53	0.06	REF
Neuropathy
Yes	89	0.57	0.04	0.03	0.55	0.04	0.07	0.54	0.04	0.05
No	1,068	0.52	0.03	REF	0.52	0.03	REF	0.50	0.03	REF
Body mass index
Normal weight	289	N/A	N/A	N/A	0.53	0.03	REF	0.52	0.04	REF
Overweight	322	N/A	N/A	N/A	0.54	0.04	0.69	0.53	0.04	0.68
Obese grade I	235	N/A	N/A	N/A	0.54	0.04	0.48	0.52	0.03	0.74
Obese grade II	151	N/A	N/A	N/A	0.54	0.03	0.56	0.53	0.04	0.72
Obese grade III	109	N/A	N/A	N/A	0.61	0.04	<0.01	0.59	0.03	<0.01
Underweight	21	N/A	N/A	N/A	0.46	0.05	0.05	0.44	0.05	0.05

BMI classifications: normal weight (BMI 18.5–24.9 kg/m²); overweight (BMI 25.0–29.9 kg/m²); obese grade I (BMI 30.0–34.9 kg/m²); obese II (BMI 35.0–39.9 kg/m²); obese III (BMI ≥ 40.0 kg/m²); underweight (BMI < 18.5 kg/m²).

All models were adjusted for sex, age at assessment, and age at diagnosis.

Nine survivors did not complete the six-minute walk and were removed from analysis due to uncontrolled asthma (1), paralysis (2), painful swelling in legs (2), acute neurological symptoms (1), chronic low back pain (2), and a recent triple bypass surgery (1).

Seven community controls were removed from analysis due to a recently placed pacemaker (1), acute angina (1), technical error (2), severe COPD (1), unable to ambulate without assistance (1), severe shortness of breath (1).

BMI, body mass index; <, less than; n, number; N/A, not applicable; R², Coefficient of determination; REF, reference.

^{^a}

Additionally adjusted for smoking status and physical activity status.