. 2022 Oct 28;10:976012. doi: 10.3389/fped.2022.976012

Table 4.

Associations between the physiological cost index, SF-36 component summaries, and adaptive physical function in adult survivors of acute lymphoblastic leukemia vs. community controls.

	SF-36						Adaptive physical function
	PCS^a			MCS^b			PPT^c			Timed up and go^a
	mean	SE	p	mean	SE	p	mean	SE	p	mean	SE	p
PCI	51.70	0.09	0.26	48.41	0.07	0.94	26.91	0.11	0.78	5.86	0.02	0.11
Group
Community controls	53.47	0.43	REF	48.83	0.53	REF	27.46	0.06	REF	5.36	0.12	REF
Survivors	50.20	0.31	<0.01	46.80	0.38	<0.01	26.59	0.09	<0.01	6.26	0.14	0.82
PA
Inactive	50.29	0.35	REF	46.78	0.46	REF	26.68	0.07	REF	6.18	0.13	REF
Active	53.43	0.34	<0.01	48.86	0.43	<0.01	27.37	0.08	<0.01	5.43	0.13	<0.01
PCI*group, control	54.71	0.14	REF	49.94	0.12	REF	27.60	0.02	REF	5.19	0.03	REF
PCI*group, survivor	50.46	0.09	0.18	47.62	0.08	0.39	26.63	0.01	0.19	6.14	0.02	<0.01

Physical activity guidelines based on the 2018 CDC recommendations of 450 metabolic equivalent minutes per week.

Interaction term was removed from the model when not significant.

Nine survivors did not complete the six-minute walk and were removed from analysis due to uncontrolled asthma (1), paralysis (2), painful swelling in legs (2), acute neurological symptoms (1), chronic low back pain (2), and a recent triple bypass surgery (1).

Seven community controls were removed from analysis due to a recently placed pacemaker (1), acute angina (1), technical error (2), severe COPD (1), unable to ambulate without assistance (1), severe shortness of breath (1).

42 (sixteen community controls, 26 survivors) did not complete their SF-36 questionnaire.

One survivor did not complete their physical performance test due to cognitive limitations.

Three survivors did not complete timed up and go due to patient refusal (1) and tester error (2).

SF-36, Medical Outcomes Survey Short-Form-36; MCS, mental component summary; PCI, physiological cost index; PCS, physical component summary; PPT, physical performance test.

^{^a}

Model additionally adjusted for age, sex, physical activity, smoking status, and race.

^{^b}

Model additionally adjusted for age, sex, physical activity, and smoking status.

^{^c}

Model additionally adjusted for physical activity, sex, and smoking status.