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. 2022 Oct 28;13:1017707. doi: 10.3389/fmicb.2022.1017707

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Copyright © 2022 Lu, Liu, Zhou, Liu, Long, Lin, Xiong, Xiao, Huang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The quorum sensing system of P. aeruginosa inhibits heteroresistance. (A) Deficiency of lasI or rhlI in PAO1 enhanced heteroresistance. *, p < 0.05, PAO1ΔlasI or PAO1ΔrhlI compared with PAO1; (B,C) Over expression of lasI or rhlI inhibited heteroresistance. *, p < 0.05, ΔlasI-LasI compared with ΔlasI-pROp200; ΔrhlI-RhlI compared with ΔrhlI-pROp200. (D,E) Exogenous 3-oxo-C12-HSL (C12) or C4-HSL (C4) inhibited heteroresistance. The HR tests (PAPs) were carried out on PAO1ΔlasI and PAO1ΔrhlI treated with 40 μM of 3-oxo-C12-HSL and C4-HSL, respectively, *, p < 0.05, ΔlasI-C12 compared with ΔlasI-DMSO; ΔrhlI-C12 compared with ΔrhlI-DMSO. ΔlasI-pROp200: PAO1ΔlasI strain transformed with pROp200 plasmid; ΔlasI-LasI: PAO1ΔlasI strain transformed with pROp200 plasmid that expressed LasI; ΔlasI-DMSO: PAO1ΔlasI strain treated with DMSO; ΔlasI-C12: PAO1ΔlasI strain treated with 3-oxo-C12-HSL; ΔrhlI-DMSO: PAO1ΔrhlI strain treated with DMSO; ΔrhlI-C4: PAO1ΔrhlI strain treated with C4-HSL.