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. 2022 Oct 25;10:975786. doi: 10.3389/fbioe.2022.975786

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Copyright © 2022 Spinner, Barnes, Puinean, Gray, Dafa’alla, Phillips, Nascimento de Souza, Frazon, Ercit, Collado, Naish, Sulston, Ll. Phillips, Greene, Poletto, Sperry, Warner, Rose, Frandsen, Verza, Gorman and Matzen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Absolute suppression chart in all areas in Indaiatuba treated with OX5034 Aedes aegypti adult males. Solid lines indicate suppression calculated for each release area, relative to the untreated control area. Shaded areas indicate 95% confidence intervals. (B) OX5034 Aedes aegypti male mosquito releases during the Indaiatuba field trial. Releases began in May 2018 (Week 22) and ended in April 2019 (Week 14). Additional buffer zone releases were added to two neighbourhoods, Morada do Sol (high dose) and Jardim Moacyr Arruda (low dose) in February 2019. (C) Post-release monitoring of the four treatment neighbourhoods demonstrated that the transgenic mosquitoes were no longer detected in the environment after 13 weeks (CECAP, Jardim Itamaracá and Jardim Moacyr Arruda), and after 24 weeks in Morada do Sol, a high-dose area with added buffer zone. Monitoring continued until 48 weeks after the end of OX5034 Aedes aegypti male releases.