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. Author manuscript; available in PMC: 2022 Dec 9.
Published in final edited form as: J Am Chem Soc. 2022 Oct 24;144(44):20463–20471. doi: 10.1021/jacs.2c09118

Figure 2. Condition Development for Alkene Aminofluorination Reaction.

Figure 2.

Conditions: 1a (2.0 equiv), 2a (0.2 mmol, 1.0 equiv), [F−] reagent, DCE (1.0 mL), 80 °C, 2 h, in 10-mL sealed FEP tube. Yields were determined by 1H NMR of the crude mixture with dibromomethane as an internal standard. Isolated yields shown in parentheses. aCu(OAc)2 (10 mol %) used. bCu(OAc)2 (10 mol %) Et3N·3HF (10 equiv), hydroxylamine derivative (1.0 equiv). c2a (1.0 equiv), Et3N·3HF (10 equiv).