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. 2022 Nov 10;141(1):73–77. doi: 10.1001/jamaophthalmol.2022.4688

Figure 1. Visual Field Worsening in Patients With Early-Manifest Glaucoma and Individuals With Suspected Glaucoma With High Polygenic Risk.

Figure 1.

A, Distribution of scaled polygenic risk score (PRS) values (z scores) for the Progression Risk of Glaucoma: Relevant SNPs With Significant Association (PROGRESSA) cohort of patients with early-manifest glaucoma and those with suspected glaucoma, compared with an unselected control population. B, Individuals in the top 5% of the population PRS distribution showed accelerated visual field loss compared with the bottom 95% PRS group.