Figure 2. Visual Field Worsening in Patients With Early-Manifest Glaucoma and Individuals With Suspected Glaucoma With Low Polygenic Risk.

Individuals in the high-risk distribution (top 5% of the population polygenic risk score [PRS]) showed a more rapid visual field worsening, whereas the low-risk distribution (bottom 20% of the population PRS) had slower worsening compared with the intermediate 75% group at 3 years (hazard ratio, 0.52; 95% CI, 0.28-0.96; P = .04) but not at 5 years.