Table. Characteristics of Individuals With Early-Manifest Glaucoma or Individuals With Suspected Glaucoma Stratified by Genetic Risk.
| Characteristic | PRS, No. (%) | P value (top 5% PRS vs bottom 95%)a | |
|---|---|---|---|
| Top 5% | Bottom 95% | ||
| No. (%) | 132 (11.97) | 971 (88.03) | NA |
| Male | 55 (41.7) | 433 (44.6) | >.99 |
| Female | 77 (58.3) | 538 (55.4) | |
| Age at enrollment, mean (SD), y | 61.48 (9.58) | 62.14 (9.91) | >.99 |
| Family history of glaucoma | 74 (56.1) | 361 (37.2) | <.001 |
| Maximum recorded IOP, mean (SD), mm Hg | 22.40 (5.41) | 21.85 (6.44) | .44 |
| No. of glaucoma drops, SLT, or trabeculectomies, mean (SD) | 1.57 (1.48) | 1.15 (1.52) | <.001 |
| Rate of pRNFL thinning in the faster progressing quadrant, μm/y | −1.64 (1.40) | −1.36 (1.30) | .01 |
| Proportion of fast pRNFL progressors, >1 μm/y, % | 47.6 | 39.6 | .02b |
Abbreviations: IOP, intraocular pressure; NA, not applicable; pRNFL, peripapillary retinal nerve fiber layer; PRS, polygenic risk score; SLT, selective laser trabeculoplasty.
a
P values represent Bonferroni-corrected post hoc pairwise comparisons between the top 5% and bottom 95% of the population PRS distribution, except for the pRNFL outcomes. Maximum recorded IOP was obtained at any points during follow-up (not exclusively pretreatment IOP).
b
Results of a binomial model: odds ratio, 1.5; 95% CI, 1.09-2.2; P = .02.