Table. Resistance rates against six antibiotics of Klebsiella variicola and non-kv-kpc isolates collected by ANRESIS, Switzerland, 1 January 2017–13 June 2022 (n = 70,114).
| Antibiotic | Non-kv-kpc | Klebsiella variicola | OR | 95% CI | p value | ||
|---|---|---|---|---|---|---|---|
| Resistant (%) | n (total) | Resistant (%) | n (total) | ||||
| Amoxicillin-clavulanic acid | 9.1 | 60,114 | 4.7 | 9,889 | 2.0 | 1.8–2.2 | < 0.001 |
| Carbapenem | 0.4 | 45,460 | 0.1 | 7,832 | 7.7 | 3.0–28.5 | < 0.001 |
| Cephalosporin 3rd/4th generation | 6.6 | 54,530 | 2.9 | 8,883 | 2.4 | 2.1–2.7 | < 0.001 |
| Ciprofloxacin | 6.9 | 59,743 | 2.1 | 9,856 | 3.4 | 2.9–3.9 | < 0.001 |
| Gentamicin | 2.8 | 37,806 | 1.7 | 6,447 | 1.6 | 1.3–2.0 | < 0.001 |
| Trimethoprim-sulfamethoxazole | 9.5 | 58,489 | 3.9 | 9,542 | 2.6 | 2.3–2.9 | < 0.001 |
ANRESIS: Swiss Centre for Antibiotic Resistance; CI: confidence interval; non-kv-kpc: non-Klebsiella variicola-Klebsiella pneumoniae-complex; OR: odds ratio.
Fisher’s exact tests were used and p values adjusted using sequential Bonferroni corrections. Non-kv-kpc refers to all species of the K. pneumoniae complex except K. variicola. Carbapenem includes imipenem and meropenem, cephalosporin 3rd/4th generation includes all third- and fourth-generation cephalosporins available in the ANRESIS database (i.e. cefepime, cefixime, cefotaxime, cefpodoxime, ceftazidime, ceftibuten and ceftriaxone). Resistant isolates consist of all isolates categorised resistant (R) by reporting laboratories.