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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Immunohorizons. 2022 Jul 25;6(7):528–542. doi: 10.4049/immunohorizons.2200050

FIGURE 6. Susceptibility of immune-experienced hosts to sepsis correlates with the basal inflammation present at the time of challenge.

FIGURE 6.

(A) Experimental design. CLP was performed 35 d after last infection in SPexp and age-matched SPfree B6 mice. Body weight and mortality were monitored over time. Serum and PBLs were collected before CLP for baseline analyses. (B) Summary data of analyte concentrations (pg/ml) before CLP. Parentheses indicate fold difference between experimental groups. (C) Survival of mice after CLP. (D) Experimental design. Thirty-five days after last infection, CLP was induced in SPfree and SPexp Swiss Webster mice. (E) Survival of Swiss Webster mice after CLP. Data are representative of at least two independent experiments with 5–20 mice per group. Error bars represent SEM.