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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Immunohorizons. 2022 Jul 25;6(7):528–542. doi: 10.4049/immunohorizons.2200050

FIGURE 8. NK cells contribute to enhanced mortality of SPexp mice during septic event.

FIGURE 8.

(A) Experimental design. SPfree and SPexp B6 mice were given 300 mg of anti-NK1.1 mAb or control IgG 10 and 12 d after last infection. Day 12 administration of mAb was given after CLP procedure. (B) Frequencies of NK cells 12 h before CLP. (C) Survival of SPfree mice (control IgG and anti-NK1.1 mAb treated). (D) Survival of SPexp mice (control IgG and anti-NK1.1 mAb treated). (E) Experimental design. SPfree and SPexp mice were given 300 μg of anti-NK1.1 mAb or control IgG 2, 4, and 6 d after last infection. Day 6 administration of mAb was given after CLP procedure. (F) Frequencies of NK cells 12 h before CLP. (G) Survival of mice after CLP. (H) Experiments 1 and 2 combined survival after CLP. Data are representative of two independent experiments with 5–20 mice per group. Error bars represent SEM. *p < 0.05, **p < 0.01, ****p < 0.0001.