Table 1.
Cohort characteristics
| Characteristic | Oral cancer cohort #1 n = 6 |
Oral cancer cohort #2 n = 11 |
Healthy subjects n = 11 |
p-level |
|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | ||
| Age (years) | 63.0 (13.2) | 57.3 (18.4) | 32.5 (7.2) | p = 0.0001δ |
| % (n) | % (n) | % (n) | ||
| Gender | ||||
| Male | 33.3 (2) | 63.6 (7) | 54.5 (6) | p = 0.4565 |
| Female | 66.7 (4) | 36.4 (4) | 45.5 (5) | |
| Self-reported ethnicity | ||||
| Hispanic/Latino | 0.0 (0) | 27.3 (3) | 0.0 (0) | p = 0.5342 |
| Not Hispanic/Latino | 100.0 (6) | 72.7 (8) | 100.0 (11) | |
| Self-reported race | ||||
| White | 100.0 (6) | 45.5 (5) | 36.4 (4) | p = 0.5593 |
| African American | 0.0 (0) | 27.3 (3) | 0.0 (0) | |
| Asian/Pacific Islander | 0.0 (0) | 18.1 (2) | 54.5 (6) | |
| Other | 0.0 (0) | 9.1 (1) | 9.1 (1) | |
| Primary tumor stage* | ||||
| cT1 | 16.7 (1) | 0.0 (0) | N/A | |
| pT1 | 50.0 (3) | 45.5 (5) | ||
| pT2 | 16.7 (1) | 18.2 (2) | ||
| pT3 | 16.7 (1) | 9.1 (1) | ||
| pT4 | 0 (0) | 27.3 (3) | ||
| Nodal status | ||||
| N+ | 33.3 (2) | 27.3 (3) | N/A | |
| N0 | 16.7 (1) | 36.4 (4) | ||
| Nx | 50.0 (3) | 36.4 (4) | ||
| Cancer site | ||||
| Tongue | 100.0 (6) | 72.7 (8) | N/A | |
| Gingiva | 0.0 (0) | 18.2 (2) | ||
| Floor of Mouth | 0.0 (0) | 9.1 (1) | ||
| Tobacco use | ||||
| Previous/Never | 83.3 (5) | 100.0 (11) | 100.0 (11) | p = 0.6051 |
| Current | 16.7 (1) | 0.0 (0) | 0.0 (0) | |
| Alcohol use | ||||
| Previous/Never | 16.7 (1) | 27.3 (3) | 54.5 (6) | p = 0.5342 |
| Current | 83.3 (5) | 72.7 (8) | 45.5 (5) | |
δindicates a significant difference between healthy subjects and both cancer cohorts
*pT1 stage assigned following neoadjuvant therapy in one case