Fig. 3.

Comprehensive analysis of target responses to the combination of miR-128-3p and miR-148a-3p overexpression. A Conserved target sites (top) and all target sites (bottom) of miR-128-3p and miR-148a-3p with respect to “conserved overlap.” Numbers in parentheses indicate the numbers of target sites. B Gene set enrichment analysis of “conserved overlap” target genes performed using the hallmark gene sets and Gene Ontology biological process gene sets in the MsigDB database. P values were calculated using a hypergeometric test. C, D Proportions of significantly downregulated genes in distinct target groups. Results for all target genes with conserved sites (C) and target genes with one conserved site (D), and no non-conserved sites are shown. For “conserved overlap” and other 8/7mer targets (8mer and 7mer targets), odds ratios (ORs) are also shown. E Probability of haplo-insufficient “conserved overlap” genes and other targets. P values were calculated by the one-tailed Wilcoxon rank sum test