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. 2022 Nov 11;20:248. doi: 10.1186/s12915-022-01447-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Evolutionary trends of target sites of broadly conserved miRNAs. A Fraction of the number of species in which “non-conserved” and conserved sites of all broadly conserved miRNAs are conserved. B Density and contour plots showing the distribution of BLS values and the number of species in which sites are conserved, as in A. Vertical and horizontal dashed lines indicate BLC cutoffs (1.8 for 8mer, 2.8 for 7mer-m8, and 3.6 for 7mer-A1) and the species number threshold (n = 62), respectively. C Conservation patterns of non-conserved sites, conserved sites, and two classes of conserved sites across 84 vertebrate species (according to the species number threshold (n = 62)). D Comparison of TargetScan miRNA classification and MirGeneDB miRNA classification (evolutionary nodes of origin (locus)). E, F Fraction of the number of species in which “non-conserved” and conserved sites for each miRNA group in TargetScan classification (E) and MirGeneDB classification (F, five major groups: Vertebrata, Gnathostomata, Eutheria, Catarrhini, and H. sapiens) are conserved. The top panels show the fraction of highly conserved sites for each miRNA group