| Sr. No |
Author/Year [Reference] |
Type of Study |
Conclusion |
| 1 |
Wang et al (2021) [48] |
Case-control |
The results of this study revealed that elevated Hs-CRP (inflammatory marker) levels along with multiple acute infarctions (imaging marker) are efficient markers for one-year stroke risk stratification in patients with minor ischemic stroke or transient ischemic attack compared with using them alone. |
| 2 |
Alikiaii et al (2021) [49] |
Systematic review |
The results of this study suggest that statin therapy has beneficial impact in patients after a stroke by reducing CRP levels. Statin therapy should be considered in these patients with stroke, irrespective of their levels of cholesterol as potential anti-inflammatory agents. |
| 3 |
Kitagawa et al (2017) [50] |
Randomized controlled trial |
During follow-up, Hs-CRP levels are good predictors of vascular events and recurrent stroke among patients of ischemic stroke. Pravastatin therapy may reduce vascular inflammation as assessed by Hs-CRP levels in study subjects with non-cardiogenic ischemic stroke. |
| 4 |
Zhou et al. (2016) [51] |
Meta- analysis |
This meta-analysis reported that patients with elevated level of Hs-CRP had 46% excessive risk of ischemic stroke but slight reduction in risk of development of hemorrhagic stroke. The association of Hs-CRP level and risk of ischemic stroke was more pronounced in men than in women. |
| 5 |
Jiménez et al (2015) [52] |
Cross-sectional |
This study concluded that even after adjustment for various cardiovascular risk factors and potential confounders; raised levels of Hs-CRP levels were associated with a greater risk of stroke. The risk of development of stroke was significantly higher among males who are hypertensive having raised Hs-CRP levels in comparison to normotensive males with low serum Hs-CRP levels. |
| 6 |
Liu et al (2014) [53] |
Prospective Cross-sectional |
This large population study concluded that CRP can be used as a screening tool to identify individuals with higher risk of ischemic stroke in Chinese population as they observed that higher Hs-CRP levels were positively associated with the risk of ischemic stroke, but not of intracranial hemorrhage and subarachnoid hemorrhage. |
