TABLE 3.

Summary of Linear Mixed Effects Models Examining the Interactive Effects of Baseline Framingham Heart Study Cardiovascular Disease Risk Score Components and Amyloid Burden on Longitudinal Inferior Temporal Tau Burden

	β Estimate (95% CI)	Standard Error	t Value	p
Age*Aβ*Time	0.02 [−0.02 to 0.06]	0.02	1.01	0.31
Sex (F)*Aβ*Time	0.02 [−0.05 to 0.08]	0.03	0.47	0.64
SBP*Aβ*Time	0.09 [0.06 to 0.12]	0.02	5.37	<0.001a
BMI*Aβ*Time	0.08 [0.05 to 0.11]	0.01	5.43	<0.001a
Smoking*Aβ*Time	−0.03 [−0.19 to 0.12]	0.08	−0.40	0.69
Diabetes*Aβ*Time	0.10 [−0.07 to 0.26]	0.09	1.14	0.25

Individual vascular risk factors that make up the FHS-CVD score were examined separately for interactive effects with Aβ on ITC tau burden across time. Each vascular risk factor (age, sex, SBP, BMI, smoking, or diabetes) was included in a separate linear mixed effects model and the model results for each vascular risk factor’s interaction with Aβ and time are shown. Models are specified as follows for each vascular risk factor: ITC tau ~ Vascular Risk Factor*Aβ*Time + Age*Time + Sex*Time + APOE ε4*Time. The model for SBP was also adjusted for antihypertensive medication use and its interaction with time

^aSignificant at FWE-corrected threshold of <0.0083.

Aβ = β-amyloid; APOE ε4 = apolipoprotein E ε4 allele; BMI = body mass index; CI = confidence interval; FHS-CVD = Framingham Heart Study cardiovascular disease risk; FWE = family-wise error; ITC = inferior temporal cortex; SBP = systolic blood pressure.