Table 1.
Clinical Trials and Comparative Studies in vitro of Medicinal Plants That Have the Potential to Treat Seborrhea Dermatitis
| Plants Name | Solvent for Extraction | Preparation Type | Concentration in Formulation | Subject | Duration of Treatment Formulation | Results | Ref. |
|---|---|---|---|---|---|---|---|
| Serratula coronata | Ethanol | Cream | 2% | 36 subjects (17 women and 19 men with age of 18–65 years) | 2 times a week (for 6 weeks) | There was a significant reduction in symptoms (p<0.05), especially in terms of pain or burning sensation, as well as itching in the affected area compared to the previous symptoms. | [14] |
| Cirsium eriophorum | – | Cream | 0.5% plant extract | 40 subjects (20–40 years) | 2 times a day for 4 weeks | Cream containing Cirsium eriophorum cell culture extract could restore the average sebum level, reduced pore size, and improved the barrier function of the epidermis significantly (p<0.05) | [15] |
| Myrtus communis | – | Cream | 0.5% plant extract | 90 subjects | Once every 3–4 days for 30 days | Myrtus communis group showing significant improvement in itching (p=0.004) | [16] |
| - After using antidandruff products, all dandruff indices increased significantly (p<0.001) compared to the baseline value | |||||||
| Apium graveolens | – | Shampoo | 3% | 60 subjects | 3 times a week for 3 weeks | The senkyunolide-A isolate significantly reduced dandruff intensity, histamine content, itching, and scalp redness compared with placebo and initial treatment. | [17] |
| Quassia amara | – | Gel | 4% (hydroglycolic extract) | 60 sebjects | 2 times a day for 4 weeks | -There was a significant decrease in mean seborrhea dermatitis score after 4 weeks of treatment, similar to or higher than that observed with ciclopiroxolamine and ketoconazole. | [18] |
| - In follow-up control 4 weeks after discontinuation of treatment, quassia showed a better reduction than the cyclopyroxolamine and ketoconazole groups. | |||||||
| Ananas comosus | Methanol | Cream | 2% | 11 subjects | 2 times a day for 12 weeks | Treatment with cream was superior to placebo because at the end of the study reduced: | |
| - Erythema index = −20.76 ± 0.89% | [19] | ||||||
| - Sebum secretion = −40.71 ± 0.75% |