Table 3.
Comparison of A/T groups on cortical thickness, vascular risk and APOE status
| Variable | A−/T− | A−/T+ | A+/T− | A+/T+ | Test statistic | P-value |
|---|---|---|---|---|---|---|
| EC thickness, mean (SD) | 3.58 (0.4) | 3.37 (0.6)a | 3.58 (0.3) | 3.24 (0.5)a | F = 12.6 | <0.001 |
| ITG thickness, mean (SD) | 2.86 (0.1) | 2.83 (0.2) | 2.87 (0.1) | 2.76 (0.2)a | F = 5.6 | <0.001 |
| Precuneus thickness, mean (SD) | 2.34 (0.1) | 2.31 (0.1) | 2.30 (0.2) | 2.23 (0.2)a | F = 5.3 | 0.001 |
| SFG thickness, mean (SD) | 2.56 (0.1) | 2.52 (0.1) | 2.51 (0.2) | 2.51 (0.1) | F = 1.2 | 0.31 |
| Pulse pressure, mean (SD) | 2.00 (0.1) | 2.00 (0.1) | 2.01 (0.1) | 2.01 (0.1) | F = 0.8 | 0.45 |
| HIS score % high risk | 45.2% | 54.2% | 50.0% | 50.7% | F = 2.2 | 0.54 |
| Global WMH, mean (SD) | 5.39 (9.1) | 6.19 (7.9) | 11.86 (16.7) | 10.3 (17.1) | χ2 = 0.6 | 0.59 |
| APOE ε4 status, % ε4 positive | 23.3% | 18.6% | 51.0%b | 64.8%c | χ2 = 116.2 | <0.001 |
EC, entorhinal cortex; HIS, Hachinski ischaemic scale; ITG, inferior temporal gyrus; SD, standard deviation; SFG, superior frontal gyrus; WMH, white matter hyperintensities.
Note that the values reported here do not reflect the transformed and residualized values used in model estimates.
a
Significantly different from the A−/T− and A+/T− groups.
b
Significantly different from the A−/T− and A−/T + groups.
c
Significantly different from all other groups.