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. 2022 Oct 28;12:986103. doi: 10.3389/fonc.2022.986103

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Copyright © 2022 Geddes, Ray, Nofchissey, Esmaeili, Saunders, Bender, Khan, Aravindan, Ahrendsen, Li, Fung, Jayaraman, Yang, Booth, Dunn, Carter and Morris

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4+ cells increased in TME of women compared to men, and in older women compared to younger. (A-C) Frequency of CD4+ staining reported as percent cells positive in tumor (22.04% vs 10.26%, p=0.002), lymph node (39.54% vs 8.56%, p=0.001), and uninvolved colon tissue (3.9% vs 2.7%, p=0.045) from men (n = 50) and women (n = 51) with colon cancer. (D) Frequency of CD4+ staining reported as percent positive cells in tumor in women ages >55 (n = 30) compared to younger than 55 (n = 14) (26.9% vs. 4.7%, p=0.002).