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. 2022 Oct 28;12:986103. doi: 10.3389/fonc.2022.986103

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Copyright © 2022 Geddes, Ray, Nofchissey, Esmaeili, Saunders, Bender, Khan, Aravindan, Ahrendsen, Li, Fung, Jayaraman, Yang, Booth, Dunn, Carter and Morris

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8+ cells are increased in normal colon tissue of women and in Stage I/II tumors. (A-C) Frequency of CD8+ staining reported as percent cells positive in tumor (34.77% vs. 29.81%, p=0.145) and lymph node (34.41% vs. 25.39%, p=0.591) were not different between men (n = 50) and women (n = 51), however, CD8+ was increased in normal tissue from women as compared to men (47.40% vs. 34.61%, p=0.015). (D) When stratified into cancer stages, CD8+ cells more frequently infiltrated tumors from stages I and II (n = 47) compared to III and IV (n = 54)(37.01% vs 23.91% p=0.009).