Table 1.
Frequency of the cytogenetic abnormality in 99 pediatric acute lymphoid leukemia patients
| Characteristic | Normal | t(12;21) | t(1;19) | t(9;22) | Hyperdiploidy | Hypodiploidy | Miscellaneous |
|---|---|---|---|---|---|---|---|
| n (%) | 35 (35.3) | 29 (29.3) | 13 (13.3) | 6 (6) | 4 (4) | 2 (2) | 10 (10.1) |
| Sex, n (%) | |||||||
| Male | 22 (62.8) | 20 (69) | 7 (53.8) | 4 (66.5) | 2 (50) | 2 (100) | 5 (50) |
| Female | 13 (13.2) | 9 (31) | 6 (46.2) | 2 (33.5) | 2 (50) | 0 | 5 (50) |
| Lineage, n (%) | |||||||
| Pre-B-ALL | 21 (60) | 25 (86.2) | 8 (61.5) | 5 (83.4) | 3 (75) | 0 | 6 (60) |
| Common B-ALL | 4 (11.5) | 1 (3.4) | 5 (38.5) | 1 (16.6) | 1 (25) | 0 | 3 (30) |
| T-ALL | 10 (28.5) | 3 (10.4) | 0 | 0 | 0 | 2 (100) | 1 (10) |
| Median age (years), n (%) | |||||||
| >1 | 1 (3) | 0 | 3 (23) | 0 | 1 (25) | 1 (50) | 1 (10) |
| 1-10 | 24 (68.5) | 26 (89.7) | 5 (38.5) | 5 (83.4) | 3 (75) | 0 | 5 (50) |
| <10 | 10 (28.5) | 3 (10.3) | 5 (38.5) | 1 (16.6) | 0 | 1 (50) | 4 (40) |
| Mediastinal mass breast, n (%) | |||||||
| Yes | 2 (5.8) | 3 (10.3) | 0 | 2 (33.5) | 0 | 0 | 3 (30) |
| No | 33 (94.2) | 26 (89.7) | 4 (66.5) | 7 (70) | |||
| Median hemoglobin (g/dl) | 8.1 (2.4-13) | 11.3 (5.3-14.9) | 9.8 (4.9-13.5) | 7.8 (2.9-10.8) | 9.8 (4.6-11.3) | 6.6 (2.4-9.8) | 10.2 (5.8-14.7) |
| Median WBC (×109 cells/µl) | 9.3 (0.5-310) | 8.9 (3.2-198) | 7.9 (3.8-208) | 31 (2.3-245) | 11.6 (1.8-174) | 27 (0.8-425) | 10.1 (1.4-370) |
| >50 | 29 (83) | 24 (83) | 9 (69) | 2 (33.4) | 3 (75) | 0 | 6 (60) |
| 50-100 | 3 (8.5) | 3 (10.3) | 3 (23) | 1 (16.6) | 1 (25) | 2 (100) | 3 (30) |
| <100 | 3 (8.5) | 2 (6.7) | 1 (8) | 3 (50) | 0 | 0 | 1 (10) |
| Median PLT (×109 cells/µl) | 52 (10-640) | 67 (25-268) | 59 (15-305) | 38 (20-299) | 49 (34-157) | 20 (16-107) | 41 (26-169) |
| Median peripheral blood blasts (%) | 61 (8-82) | 51 (4-91) | 63 (7-76) | 68 (11-84) | 55 (6-88) | 77 (16-91) | 59 (5-89) |
| Survival outcomes (at 5 year) (%) | |||||||
| OSR | 48 | 45 | 41 | 24 | 40 | 23 | 38 |
| EFS | 39 | 35 | 29 | 24 | 28 | 17 | 25 |
| Median LDH (IU/l), n (%) | 987 (461-6900) | 801 (357-2661) | 823 (389-1520) | 768 (402-1891) | 545 (380-1123) | 891 (763-979) | 669 (440-3521) |
| >500 | 7 (20) | 19 (56.5) | 8 (61.5) | 2 (33.3) | 3 (75) | 0 | 6 (60) |
| 500-1000 | 25 (71.5) | 7 (24.1) | 3 (23.2) | 3 (50) | 1 (25) | 2 (100) | 2 (20) |
| <1000 | 3 (8.5) | 3 (10.4) | 2 (15.3) | 1 (16.7) | 0 | 0 | 2 (20) |
Miscellaneous subgroup comprised patients with mosaic down syndrome, trisomy 21, monosomy 7, inversion 16, and t(8;12). ALL: Acute lymphoid leukemia, OSR: Overall survival rate, EFS: Event-free survival, WBCs: White blood cells, PLTs: Platelets, LDH: Lactate dehydrogenase