Figure 2. Estimated Changes in Total Brain, AD Signature Region, White Matter and Temporal White Matter Volumes (cm3) Associated With sHHV Diagnoses.
Estimated volumes derived from linear mixed-effects models were adjusted for baseline intracranial volume, age, sex, race, education, APOEε4, comorbidity index (i.e., obesity, hypertension, diabetes, cancer, ischemic heart disease, chronic heart failure, chronic kidney disease, and chronic obstructive pulmonary disease), and 2-way interactions of age, sex, race, education, APOEε4, and comorbidity index with time. βs and corresponding p values represent adjusted differences in estimated annual brain volume changes between groups (sHHV+/−). AD = Alzheimer disease; sHHV = symptomatic human herpes virus.